Francis M. Sirotnak: search on Z-Library

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1

Quantitation of the synergistic interaction of edatrexate and cisplatin in vitro

Ting-Chao Chou, Queng-Hui Tan, Francis M. Sirotnak

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1993

Language:

english

File:

PDF, 611 KB

english, 1993

2

Edatrexate, an Antifolate with Antitumor Activity: A Review

Grant, Stefan C., Kris, Mark G., Young, Charles W., Sirotnak, Francis M.

Journal:

Cancer Investigation

Year:

1993

Language:

english

File:

PDF, 905 KB

english, 1993

3

Hyperproduction mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae: Some effects on synthesis correlate with the presence of a modified enzyme form

Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1973

Language:

english

File:

PDF, 377 KB

english, 1973

4

Analog specific aberrancies in antifolate inhibition of L1210 cell dihydrofolate reductase

Francis M. Sirotnak, Paul L. Chello, Donna M. Moccio, James R. Piper, John A. Montgomery, James C. Parham

Journal:

Biochemical Pharmacology

Year:

1980

Language:

english

File:

PDF, 701 KB

english, 1980

5

Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells

Scott R. Schlemmer, Francis M. Sirotnak

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 654 KB

english, 1995

6

Proliferation-dependency of folylpolyglutamyl synthetase activity in maturating luminal epithelial cells of mouse small intestine

Francis M. Sirotnak, Thomas B. Johnson, Larry L. Samuels, John Galivan

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 395 KB

english, 1988

7

On the Size of Genetic Determinants in Pneumococcus and the Nature of the Variables Involved in Transformation

Barbara H. Rosenberg, Francis M. Sirotnak and Liebe F. Cavalieri

Journal:

Proceedings of the National Academy of Sciences

Year:

1959

Language:

english

File:

PDF, 446 KB

english, 1959

8

Antifolate transport in L1210 leukemia cells. Kinetic evidence for the non-identity of carriers for influx and efflux

Micah Dembo, Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1976

Language:

english

File:

PDF, 670 KB

english, 1976

9

Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives

Francis M. Sirotnak, Glenys M. Otter, J.Robert Piper, Joseph I. Degraw

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 314 KB

english, 1988

10

Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of methotrexate-pretreated mice

Marlene A. Bunni, Francis M. Sirotnak…

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1994

Language:

english

File:

PDF, 447 KB

english, 1994

11

A new human peptide deformylase inhibitable by actinonin

Mona D Lee, Christophe Antczak, Yueming Li, Francis M Sirotnak, William G Bornmann, David A Scheinberg

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 265 KB

english, 2003

12

Evidence for a genetic alteration of dihydrofolate reductase associated with amethopterin resistance in Diplococcus pneumoniae

Francis M. Sirotnak, Gloria J. Donati, Dorris J. Hutchison

Journal:

Biochemical and Biophysical Research Communications

Year:

1964

Language:

english

File:

PDF, 175 KB

english, 1964

13

Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites

James J. Kinahan, Lawrence L. Samuels, Fouad Farag, Michael P. Fanucchi, Pedro M. Vidal, Francis M. Sirotnak, Charles W. Young

Journal:

Analytical Biochemistry

Year:

1985

Language:

english

File:

PDF, 859 KB

english, 1985

14

Correlates of folate analog transport, pharmacokinetics and selective antitumor action

Francis M. Sirotnak

Journal:

Pharmacology & Therapeutics

Year:

1980

Language:

english

File:

PDF, 2.63 MB

english, 1980

15

Gel filtration properties of mutant and wild-type dihydrofoiate reductase from Diplococcuspneumoniae

Francis M. Sirotnak, Dorris J. Hutchison

Journal:

Biochemical and Biophysical Research Communications

Year:

1965

Language:

english

File:

PDF, 251 KB

english, 1965

16

Synthesis and antifolate activity of 8,10-dideazaminopterin

Joseph I. Degraw, Lawrence F. Kelly, Roy L. Kisliuk, Yvette Gaumont, Francis M. Sirotnak

Journal:

Journal of Heterocyclic Chemistry

Year:

1982

File:

PDF, 144 KB

1982

17

Studies with ZD1839 in preclinical models

Francis M Sirotnak

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

18

The Secalosides, Novel Tumor Cell Growth Inhibitory Glycosides from a Pollen Extract

Jaton, Jean-Claude, Roulin, Karen, Rose, Keith, Sirotnak, Francis M., Lewenstein, Ari, Brunner, Gérard, Fankhauser, Catherine P., Burger, Ulrich

Journal:

Journal of Natural Products

Year:

1997

Language:

english

File:

PDF, 198 KB

english, 1997

19

Further evaluation of 5-alkyl-5-deaza antifolates. 5-propyl- and 5-butyl-5-deaza analogues of aminopterin and methotrexate

James R. Piper, Balakrishnan Ramamurthy, Cheryl A. Johnson, Joseph A. Maddry, Glenys M. Otter, Francis M. Sirotnak

Journal:

Journal of Heterocyclic Chemistry

Year:

1995

File:

PDF, 624 KB

1995

20

Synthesis and Properties of 10-Benzylaminopterin

James C. Parham, Mary Agnes Templeton, Paul L. Chello, Francis M. Sirotnak

Journal:

Journal of Heterocyclic Chemistry

Year:

1979

File:

PDF, 157 KB

1979

21

Studies on analogs of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain

Piper, James R., Johnson, Cheryl A., Maddry, Joseph A., Malik, Neeta D., McGuire, John J., Otter, Glenys M., Sirotnak, Francis M.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 2.49 MB

english, 1993

22

Studies on analogs of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain. [Erratum to document cited in CA120:192237]

Piper, James R., Johnson, Cheryl A., Maddry, Joseph A., Malik, Neeta D., McGuire, John J., Otter, Glenys M., Sirotnak, Francis M.

Journal:

Journal of Medicinal Chemistry

Year:

1994

File:

PDF, 28 KB

1994

23

Methotrexate Resistance in an in vivo Mouse Tumor Due to a Non-Active-Site Dihydrofolate Reductase Mutation

Adam P. Dicker, Mark C. Waltham, Matthias Volkenandt, Barry I. Schweitzer, Glenys M. Otter, Franz a. Schmid, Francis M. Sirotnak and Joseph R. Bertino

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.22 MB

english, 1993

24

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Lee, Mona D., She, Yuhong, Soskis, Michael J., Borella, Christopher P., Gardner, Jeffrey R., Hayes, Paula A., Dy, Benzon M., Heaney, Mark L., Philips, Mark R., Bornmann, William G., Sirotnak, Francis

Journal:

Journal of Clinical Investigation

Year:

2004

Language:

english

File:

PDF, 652 KB

english, 2004

25

Schedule-dependent synergism of taxol or taxotere with edatrexate against human breast cancer cells in vitro

Ting-Chao Chou, Glenys M. Otter, Francis M. Sirotnak

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 702 KB

english, 1996

26

Chemical synthesis and biological activities of 5-deazaaminopterin analogs bearing substituent(s) at the 5- and/or 7-position(s)

Su, Tsann Long, Huang, Jai Tung, Chou, Ting Chao, Otter, Glenys M., Sirotnak, Francis M., Watanabe, Kyoichi A.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 916 KB

english, 1988

27

A basis for the difference in toxicity of methotrexate, aminopterin and methasquin in mice

Francis M. Sirotnak, Ruth C. Donsbach

Journal:

Biochemical Pharmacology

Year:

1975

Language:

english

File:

PDF, 254 KB

english, 1975

28

Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells

Richard G. Poser, Francis M. Sirotnak, Paul L. Chello

Journal:

Biochemical Pharmacology

Year:

1980

Language:

english

File:

PDF, 269 KB

english, 1980

29

Stereospecificity at carbon 6 of formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

Francis M. Sirotnak, Paul L. Chello, Donna M. Moccio, Roy L. Kisliuk, Gilbert Combepine, Yvette Gaumont, John A. Montgomery

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 673 KB

english, 1979

30

Growth inhibitory, transport and biochemical properties of the γ-glutamyl and γ-aspartyl peptides of methotrexate inL1210 leukemia cells in vitro

Francis M. Sirotnak, Paul L. Chello, James R. Piper, John A. Montgomery

Journal:

Biochemical Pharmacology

Year:

1978

Language:

english

File:

PDF, 586 KB

english, 1978

31

Regulation of transcription of the human MRP7 gene: Characteristics of the basal promoter and identification of tumor-derived transcripts encoding additional 5′ end heterogeneity

Magdalena Dabrowska, Francis M. Sirotnak

Journal:

Year:

2004

Language:

english

File:

PDF, 888 KB

english, 2004

32

Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase

Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1973

Language:

english

File:

PDF, 641 KB

english, 1973

33

Further studies of stereospecificity at carbon 6 for membrane transport of tetrahydrofolates: Diastereoisomers of 5-methyltetrahydrofolates as competitive inhibitors of transport of methotrexate in L1210 cells

Paul L. Chello, Francis M. Sirotnak, Ellen Wong, Roy L. Kisliuk, Yvette Gaumont, Gilbert Combepine

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 504 KB

english, 1982

34

Analogues of 10-Deazaaminopterin and 5-Alkyl-5,10-dideazaaminopterin with the 4-Substituted 1-Naphthoyl Group in the Place of 4-Substituted Benzoyl

Piper, James R., Ramamurthy, Balakrishnan, Johnson, Cheryl A., Otter, Glenys M., Sirotnak, Francis M.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 107 KB

english, 1996

35

9-Substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships

Su, Tsann-Long, Chou, Ting-Chao, Kim, Joong Young, Huang, Jai-Tung, Ciszewska, Grazyna, Ren, Wu-Yun, Otter, Grenys M., Sirotnak, Francis M., Watanabe, Kyoichi A.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.70 MB

english, 1995

36

E2F site in the essential promoter region does not confer S phase-specific transcription of the ABCC10 gene in human prostate cancer cells

Dabrowska, Magdalena, Sirotnak, Francis M.

Journal:

Acta Biochimica Polonica

Year:

2017

Language:

english

File:

PDF, 441 KB

english, 2017

37

Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins

DeGraw, Joseph I., Christie, Pamela H., Kisliuk, Roy L., Gaumont, Yvette, Sirotnak, Francis M.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 588 KB

english, 1990

38

Transformation of Resistance to 8-Azaguanine in Diplococcus pneumoniae

SIROTNAK, FRANCIS M., LUNT, RAMONA B., HUTCHISON, DORRIS J.

Journal:

Year:

1960

File:

PDF, 223 KB

1960

39

Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue

Lawrence L. Samuels, Aaron Feinberg, Donna M. Moccio, Francis M. Sirotnak, Gerald Rosen

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 319 KB

english, 1984

40

Absorption of deoxyribonucleic acid by mouse lymphoma cells

Francis M. Sirotnak, Dorris J. Hutchison

Journal:

Biochimica et Biophysica Acta

Year:

1959

Language:

english

File:

PDF, 196 KB

english, 1959

41

Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin

DeGraw, Joseph I., Christie, Pamela H., Colwell, William T., Sirotnak, Francis M.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 703 KB

english, 1992

42

Thymidylate synthetase from Diplococcus pneumoniae properties and inhibition by folate analogs

Robert W. McCuen, Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1975

Language:

english

File:

PDF, 689 KB

english, 1975

43

Sequential combination of metliotrexate and vindesine in previously treated children with acute leukemia

Miller, Linda P., Hancock, Counce, Miller, Denis R., Chello, Paul L., Sirotnak, Francis M., Tan, Charlotte T. C.

Journal:

American Journal of Clinical Oncology

Year:

1984

File:

PDF, 398 KB

1984

44

Carrier-mediated transport of folate compounds in L1210 cells: Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

Francis M. Sirotnak, Lydia J. Goutas, Donna M. Jacobsen, Laurie S. Mines, JoséR. Barrueco, Yvette Gaumont, Roy L. Kisliuk

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 1.06 MB

english, 1987

45

Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin

DeGraw, Joseph I., Colwell, William T., Piper, James R., Sirotnak, Francis M.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 409 KB

english, 1993

46

Up-regulation of intestinal folate uptake process in dietary folate deficiency: Functional and molecular mechanisms

Said, Hamid M., Chatterjee, Nabendu, Haq, Riaz, Subramanian, Veedamali, Ortiz, Alvaro, Matherly, Larry, Sirotnak, Francis, Halsted, Charles

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 190 KB

english, 2000

47

Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogs of methotrexate and tetrahydrofolic acid

DeGraw, Joseph I., Christie, Pamela H., Kisliuk, Roy L., Gaumont, Yvette, Sirotnak, Francis M.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 690 KB

english, 1990

48

Pharmacokinetics of methotrexate in leukemia cells: Effect of dose and mode of injection

Jonas M. Weissbrod, Rakesh K. Jain, Francis M. Sirotnak

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1978

Language:

english

File:

PDF, 832 KB

english, 1978

49

Retentiveness of methotrexate polyglutamates in cultured L1210 cells: Evidence against a role for mediated plasma membrane transport outward

Scott R. Schlemmer, Francis M. Sirotnak

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 714 KB

english, 1993

50

Chromatographic repair of storage-inactivated dihydrofolate reductase from Diplococcus pneumoniae

Francis M. Sirotnak, Dorris J. Hutchison

Journal:

Archives of Biochemistry and Biophysics

Year:

1967

Language:

english

File:

PDF, 446 KB

english, 1967

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